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1. Codon-optimization of the hemagglutinin gene from the novel swine origin H1N1 influenza virus has differential effects on CD4(+) T-cell responses and immune effector mechanisms following DNA electroporation in mice

   2010 - DNA electroporation is a powerful vaccine strategy that could be rapidly adapted to address emerging viruses. We therefore compared cellular and humoral immune responses in mice vaccinated with DNA …

2. HiLive – Real-Time Mapping of Illumina Reads while Sequencing

3. Dual RNA-seq reveals no plastic transcriptional response of the coccidian parasite Eimeria falciformis to host immune defenses

4. Influenza viruses control the vertebrate type I interferon system: factors, mechanisms, and consequences

   2009 - Virus research of the past decades showed that the vertebrate type I interferon (IFN) system is in principle capable of slowing down the replication and spread of most if not all viruses at early …

5. Resonance Raman microscopy in combination with partial dark-field microscopy lights up a new path in malaria

   2009 - Our goal is to produce a rapid and accurate diagnostic tool for malaria using resonance Raman spectroscopy to detect small inclusions of haemozoin in Plasmodium falciparum infected red blood cells. In …

6. Gene Gun-supported DNA Immunisation of Chicken for Straightforward Production of Poxvirus-specific IgY Antibodies

   2009 - Orthopoxviruses code for numerous immunomodulatory proteins, the structure and function of which are clarified inadequately. Antibodies constitute a potent tool to study such proteins, enabling …

7. Development of a live-attenuated influenza B DeltaNS1 intranasal vaccine candidate

   2009 - We discovered a unique, single amino acid mutation in the influenza B M1 protein promoting viral growth of NS1 truncation mutants in Vero cells. Due to this mutation, we were able to generate an …

8. Transcription of the phage-encoded Panton-Valentine leukocidin of Staphylococcus aureus is dependent on the phage life-cycle and on the host background

   2009 - Panton-Valentine Leukocidin (PVL) is a pore-forming, bi-component toxin secreted by Staphylococcus aureus strains epidemiologically associated with diseases such as necrotizing pneumonia and skin and …

9. Comment on “The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans”

10. Automated pipeline for purification, biophysical and x-ray analysis of biomacromolecular solutions

11. High-level ciprofloxacin resistance among hospital-adapted Enterococcus faecium (CC17)

    2009 - Hospital-adapted Enterococcus faecium differ from their colonising variants in humans and animals by additional genomic content. Molecular typing based on multilocus sequence typing (MLST) allows …

12. Vitamin D status as an international issue: national surveys and the problem of standardization

    2012 - Wide spread variation in measurement results of total 25-hydroxyvitamin D (25(OH)D) confounds international efforts to develop evidence-based clinical guidelines. Accordingly, NIH Office of Dietary …

13. An outbreak of oropharyngeal tularaemia linked to natural spring water

    2009 - A tularaemia outbreak was investigated involving 188 suspected cases in the Kocaeli region of Turkey between December 2004 and April 2005. A case–control study comprising 135 laboratory-confirmed …

14. Cardiovascular Disease

    Cardiovascular diseases are the leading cause of death in Germany, causing a total of approximately 40% of all deaths. In addition, they are associated with significant health consequences for the …

15. Successful treatment of relapsing disseminated coccidioidomycosis with cutaneous involvement with posaconazole

    2009 - A 52-year-old woman with pulmonary sarcoidosis on immunosuppressive therapy developed pulmonary infiltrates and cutaneous granulomatous abscesses after a trip to the USA in April 2005. A hyphomycete …

16. Community-acquired methicillin-resistant Staphylococcus aureus: what do we need to know?

    2009 - Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has become a matter of concern worldwide, in particular in the USA. For the analysis of emergence and spread, clear …

17. Influenza B mutant viruses with truncated NS1 proteins grow efficiently in Vero cells and are immunogenic in mice

    2009 - Contemporary influenza B virus strains were generated encoding C-terminally truncated NS1 proteins. Viable viruses containing the N-terminal 14, 38, 57 or 80 aa of the NS1 protein were rescued in Vero …

18. Zusammenarbeit nationaler und europäischer Behörden im Bereich lebensmittelbedingter Zoonosen. [Intersectoral collaboration of institutions in Germany and Europe in the field of food-borne zoonoses].

    2009 - Die Prävention und Kontrolle lebensmittelbedingter Zoonosen hat im nationalen und europäischen Kontext einen hohen Stellenwert. Um zielgerichtete Kontrollmaßnahmen ergreifen zu können, werden …

19. Einfluss der demografischen Alterung auf die Inanspruchnahme der medizinischen Rehabilitation in Deutschland bis 2040

20. Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort

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