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In vitro Activity of Tigecycline and Molecular Characterization of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Isolates from a University Hospital in South-Western Germany
2012 - Background: Extended-spectrum β-lactamase (ESBL)-producing organisms are spreading worldwide in hospital and community settings. Methods: A total of 328 unduplicated ESBL-producing Enterobacteriaceae …
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Genome Diversity and Host Interaction of Noroviruses. Chapter 12
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Host-Driven Plasticity of the Human Immunodeficiency Virus Genome. Chapter 9
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Influenza A viruses target type II pneumocytes in the human lung
2012 - Background. Highly pathogenic avian H5N1 influenza viruses preferentially infect alveolar type II pneumocytes in human lung. However, it is unknown whether this cellular tropism contributes to high …
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Need for long-term follow-up in enterohemorrhagic Escherichia coli-associated hemolytic uremic syndrome due to late-emerging sequelae
2012 - Background. The aim of this study was to evaluate the long-term prognosis of children with hemolytic uremic syndrome (HUS). Methods. Over a 6-year period, 619 pediatric patients with the clinical …
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Illegitimate recombination: An efficient method for random mutagenesis in Mycobacterium avium subsp. hominissuis.
2012 - Background The genus Mycobacterium (M.) comprises highly pathogenic bacteria such as M. tuberculosis as well as environmental opportunistic bacteria called non-tuberculous mycobacteria (NTM). While …
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Diagnostik von β-Lactamasen bei gram-negativen Infektionserregern
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Personal attributes that influence the adequate management of hypertension and dyslipidemia in patients with type 2 diabetes. Results from the DIAB-CORE Cooperation
2012 - Background Hypertension and dyslipidemia are often insufficiently controlled in persons with type 2 diabetes (T2D) in Germany. In the current study we evaluated individual characteristics that are …
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Direct Detection and Genotyping of KPC Carbapenemases from Urine using a new DNA Microarray Test
2012 - Klebsiella pneumoniae carbapenemases (KPC) are considered a serious threat to antibiotic therapy as they confer resistance to carbapenems, which are used to treat Extended-spectrum beta-lactamase …
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FliA expression analysis and influence of the regulatory proteins RpoN, FleQ and FliA on virulence and in vivo fitness in Legionella pneumophila
2012 - In Legionella pneumophila, the regulation of the flagellum and the expression of virulence traits are linked. FleQ, RpoN and FliA are the major regulators of the flagellar regulon. We demonstrated …
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Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients
2012 - Background The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a …
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Human papillomavirus vaccine uptake, knowledge and attitude among 10th grade students in Berlin, Germany, 2010
2012 - Purpose: Since March 2007, the Standing Committee on Vaccination (STIKO) recommends HPV vaccination for all 12-17 year-old females in Germany. In the absence of an immunization register, we aimed at …
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Demografie und Spendeaktivität von Blut- und Plasmaspendern in Deutschland. Update 2010 und 5-Jahres-Vergleich.
2012 - Seit 2006 erhebt das Robert Koch-Institut im Rahmen der Blutspendersurveillance neben infektionsepidemiologischen Daten auch Informationen zur Anzahl der Spender in Deutschland. Die vorliegende …
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HIV-, HCV-, HBV- und Syphilissurveillance unter Blutspendern in Deutschland 2008–2010
2012 - Im Rahmen der Blutspendersurveillance gemäß § 22 Transfusionsgesetz werden infektionsepidemiologische Daten zur Infektionshäufigkeit von HIV-, Hepatitis-C-Virus (HCV)-, Hepatitis-B-Virus (HBV)- und …
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Erste Ergebnisse aus der „Studie zur Gesundheit Erwachsener in Deutschland“ (DEGS).
2012 - Ein halbes Jahr nach Beendigung der Feldarbeit des neuen Gesundheitsuntersuchungssurveys für Erwachsene (DEGS) veröffentlicht das Robert Koch-Institut erste Ergebnisse. Unter dem Motto „Gemessen und …
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XMRV ist nicht human-pathogen und hat keine Bedeutung für die Sicherheit von Blut und Blutprodukten
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Prävention der nosokomialen Übertragung von humanem Immunschwächevirus (HIV) durch HIV-positive Mitarbeiterinnen und Mitarbeiter im Gesundheitswesen. Empfehlungen der Deutschen Vereinigung zur Bekämpfung der Viruskrankheiten (DVV) e.V. und der Gesellschaft für Virologie (GfV) e.V.
2012 - Die Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten (DVV) e.V. und die Gesellschaft für Virologie (GfV) e.V. geben nach unserem Wissen erstmalig in Europa konkrete Empfehlungen zum Einsatz …
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Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation
2012 - Follicular T-helper (TFH) cells cooperate with GL7+CD95+ germinal center (GC) B cells to induce antibody maturation. Herein, we identify the transcription factor IRF4 as a T-cell intrinsic …
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Elevation in Type I Interferons Inhibits HCN1 and Slows Cortical Neuronal Oscillations
2012 - Central nervous system (CNS) inflammation involves the generation of inducible cytokines such as interferons (IFNs) and alterations in brain activity, yet the interplay of both is not well understood. …
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Richtlinie der Gendiagnostik- Kommission (GEKO) für die Anforderungen an die Inhalte der Aufklärung bei genetischen Untersuchungen zu medizinischen Zwecken gemäß § 23 Abs. 2 Nr. 3 GenDG in der Fassung vom 27.04.2012, veröffentlicht und in Kraft getreten am 25.05.2012
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