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1. The mumps virus small hydrophobic protein targets ataxin-1 ubiquitin-like interacting protein (ubiquilin 4)

   2010 - The small hydrophobic (SH) protein of mumps virus has been reported to interfere with innate immunity by inhibiting TNF-alpha-mediated apoptosis. In a yeast two-hybrid screen we have identified the …

2. The Impact of Having a Loved One With Alcohol Consumption-Related Problems on Subjective Health Status and Health-Risk Behaviors in a General Hospital Sample

   2010 - Consecutively admitted inpatients of a general hospital in Northern Germany (N = 2903) completed a standardized screening questionnaire in 2005-2006 containing questions about alcohol …

3. Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference

   2010 - EUROPRISE is a Network of Excellence sponsored from 2007 to 2011 by the European Commission within the 6th Framework Program. The Network encompasses a wide portfolio of activities ranging from an …

4. Hepatitis B Virus Infections Among Children and Adolescents in Germany: Migration Background as a Risk Factor in a Low Seroprevalence Population

   2010 - BACKGROUND: Data on hepatitis B (HB) infection prevalence among children and adolescents in Germany are scarce. We estimated seroprevalence of HB infection and assessed determinants for HB infection …

5. Size and Mechanical Stability of Norovirus Capsids depend on pH - A Nanoindentation Study

   2010 - Norovirus - like particles (VLPs), were imaged with Atomic Force Microscopy. The mechanical stability of the VLPs was probed by nanoindentation at pH values ranging from 2 - 10. This range includes pH …

6. Evolutionary analysis and distribution of type III effector genes in pathogenic Escherichia coli from human, animal and food sources

   2010 - Molecular analysis of Shiga toxin-producing Escherichia coli (STEC) from different sources is considered as a major approach to assess their risk potential. However, only limited data are available …

7. Herausforderungen an die Gesundheitsforschung für eine alternde Gesellschaft am Beispiel „Multimorbidität“. [Challenges to health research for aging populations using the example of “multimorbidity”].

   2010 - Indem ein wachsender Anteil der Bevölkerung ein hohes Alter erreicht, ändern sich Krankheitsspektrum und Versorgungsbedarf. Besondere Herausforderungen für das Gesundheitssystem ergeben sich durch …

9. Differentiation between polymorphisms and resistance-associated mutations in human cytomegalovirus DNA polymerase

   2010 - Specific mutations in the human cytomegalovirus (HCMV) DNA polymerase (pUL54) are known to confer resistance against all currently licensed drugs for treatment of HCMV infection and disease. Following …

10. Preventing the pollution of mitochondrial datasets with nuclear mitochondrial paralogs (numts)

    2010 - Molecular tools have become prominent in ecology and evolution. A target of choice for molecular ecologists and evolutionists is mitochondrial DNA (mtDNA), whose many advantages have also convinced …

11. Phospholipase PlaB is a new virulence factor of Legionella pneumophila

    2010 - We previously identified Legionella pneumophila PlaB as the major cell-associated phospholipase A/lysophospholipase A with contact-dependent hemolytic activity. In this study, we further characterized …

12. Codon 129 polymorphism and the E200K mutation do not affect the cellular prion protein isoform composition in the cerebrospinal fluid from patients with Creutzfeldt-Jakob disease

    2010 - The cellular prion protein (PrPc) is a multifunctional, highly conserved and ubiquitously expressed protein. It undergoes a number of modifications during its post-translational processing, resulting …

13. The German case-control scene investigation study on SIDS: epidemiological approach and main results

    2010 - The present study, which was part of the German SIDS Study (GeSID), enrolled sudden infant death syndrome (SIDS) cases and population controls and obtained objective scene data via specifically …

14. Chronische Erkrankungen - Epidemiologische Entwicklung und die Bedeutung für die öffentliche Gesundheit

    2010 - Auch heute sind akute, lebensbedrohliche Infektionserkrankungen nach wie vor eine große Gefahr für die öffentlicheGesundheit. Dennoch dominieren chronische Erkrankungen, die mittlerweile sowohl …

15. Regional differences in body fat distributions among people with comparable body mass index: a comparison across six German population-based surveys

    2010 - Introduction: The mortality of circulatory diseases of the German population varies considerably across regions. The comparison of the regional distributions of cardiovascular risk factors can provide …

16. Interferon Beta modulates endothelial damage in patients with cardiac persistence of human parvovirus b19 infection

    2010 - Background. In a phase 1 study, we investigated whether interferon beta reduced endothelial damage in patients with cardiac persistence of human parvovirus B19 (B19V) infection. Methods and results. …

17. Multicolour, multiplex real-time PCR assay for the detection of human-pathogenic poxviruses. Short Communication

    2010 - After eradication of variola virus, one of the most dangerous infectious diseases affecting mankind, today other poxviruses of different genera can cause infections of humans. These viruses include …

18. Evolution and population structure of Salmonella enterica serovar Newport

    2010 - Salmonellosis caused by Salmonella enterica serovar Newport is a major global public health concern, particularly because S. Newport isolates that are resistant to multiple drugs (MDR), including …

19. Mumps Outbreak in the Republic of Moldova, 2007-2008

    2010 - BACKGROUND: Moldova experienced a nationwide mumps outbreak between 2007 and 2008. Single-dose monovalent mumps vaccination at 15 to 18 months was introduced in 1983, replaced by a 2-dose MMR schedule …

20. Diagnostic approach for the differentiation of the pandemic influenza A(H1N1)v virus from recent human influenza viruses by real-time PCR

    2010 - BACKGROUND: The current spread of pandemic influenza A(H1N1)v virus necessitates an intensified surveillance of influenza virus infections worldwide. So far, in many laboratories routine diagnostics …

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