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Influenza viruses control the vertebrate type I interferon system: factors, mechanisms, and consequences
2009 - Virus research of the past decades showed that the vertebrate type I interferon (IFN) system is in principle capable of slowing down the replication and spread of most if not all viruses at early …
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Resonance Raman microscopy in combination with partial dark-field microscopy lights up a new path in malaria
2009 - Our goal is to produce a rapid and accurate diagnostic tool for malaria using resonance Raman spectroscopy to detect small inclusions of haemozoin in Plasmodium falciparum infected red blood cells. In …
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Gene Gun-supported DNA Immunisation of Chicken for Straightforward Production of Poxvirus-specific IgY Antibodies
2009 - Orthopoxviruses code for numerous immunomodulatory proteins, the structure and function of which are clarified inadequately. Antibodies constitute a potent tool to study such proteins, enabling …
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Development of a live-attenuated influenza B DeltaNS1 intranasal vaccine candidate
2009 - We discovered a unique, single amino acid mutation in the influenza B M1 protein promoting viral growth of NS1 truncation mutants in Vero cells. Due to this mutation, we were able to generate an …
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Transcription of the phage-encoded Panton-Valentine leukocidin of Staphylococcus aureus is dependent on the phage life-cycle and on the host background
2009 - Panton-Valentine Leukocidin (PVL) is a pore-forming, bi-component toxin secreted by Staphylococcus aureus strains epidemiologically associated with diseases such as necrotizing pneumonia and skin and …
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High-level ciprofloxacin resistance among hospital-adapted Enterococcus faecium (CC17)
2009 - Hospital-adapted Enterococcus faecium differ from their colonising variants in humans and animals by additional genomic content. Molecular typing based on multilocus sequence typing (MLST) allows …
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An outbreak of oropharyngeal tularaemia linked to natural spring water
2009 - A tularaemia outbreak was investigated involving 188 suspected cases in the Kocaeli region of Turkey between December 2004 and April 2005. A case–control study comprising 135 laboratory-confirmed …
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Successful treatment of relapsing disseminated coccidioidomycosis with cutaneous involvement with posaconazole
2009 - A 52-year-old woman with pulmonary sarcoidosis on immunosuppressive therapy developed pulmonary infiltrates and cutaneous granulomatous abscesses after a trip to the USA in April 2005. A hyphomycete …
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Community-acquired methicillin-resistant Staphylococcus aureus: what do we need to know?
2009 - Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has become a matter of concern worldwide, in particular in the USA. For the analysis of emergence and spread, clear …
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Influenza B mutant viruses with truncated NS1 proteins grow efficiently in Vero cells and are immunogenic in mice
2009 - Contemporary influenza B virus strains were generated encoding C-terminally truncated NS1 proteins. Viable viruses containing the N-terminal 14, 38, 57 or 80 aa of the NS1 protein were rescued in Vero …
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Zusammenarbeit nationaler und europäischer Behörden im Bereich lebensmittelbedingter Zoonosen. [Intersectoral collaboration of institutions in Germany and Europe in the field of food-borne zoonoses].
2009 - Die Prävention und Kontrolle lebensmittelbedingter Zoonosen hat im nationalen und europäischen Kontext einen hohen Stellenwert. Um zielgerichtete Kontrollmaßnahmen ergreifen zu können, werden …
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Nasal colonization of humans with methicillin-resistant Staphylococcus aureus (MRSA) CC398 with and without exposure to pigs
2009 - Background Studies in several European countries and in North America revealed a frequent nasal colonization of livestock with MRSA CC398 and also in humans with direct professional exposure to …
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Cytomegaloviruses inhibit Bak- and Bax-mediated apoptosis with two separate viral proteins
2009 - Apoptosis of infected cells can limit virus replication and serves as an innate defense mechanism against viral infections. Consequently, viruses delay apoptosis by expressing antiapoptotic proteins, …
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Oseltamivir-resistant influenza A(H1N1) viruses detected in Europe during season 2007-8 had epidemiologic and clinical characteristics similar to co-circulating susceptible A(H1N1) viruses
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Reported beverage consumed and alcohol-related diseases among male hospital inpatients with problem drinking
2009 - Aims: The aim of this study was to examine if problem drinkers have varying risks of having alcohol-related diseases according to their reported beverage consumed. Methods: In a cross-sectional study …
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Investigating outbreaks: medical imperative or academic indulgence?
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Cutting Edge: Plasmacytoid Dendritic Cells Induce IL-10 Production in T Cells via the Delta-Like-4/Notch Axis
2009 - Proinflammatory Th1 cells can produce large amounts of the immunosuppressive cytokine IL-10, thereby facilitating the self-limitation of inflammatory responses. Recently, we identified the Notch …
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Vacuolar protein sorting pathway contributes to the release of Marburg virus
2009 - VP40, the major matrix protein of Marburg virus, is the main driving force for viral budding. Additionally, cellular factors are likely to play an important role in the release of progeny virus. In …
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Intervention epidemiology training programs in Germany and Europe. An investment in our future (abstract in English)
2009 - Outbreaks of infectious diseases such as SARS and influenza can have a profound impact on society. Therefore, training epidemiologists in infectious diseases control is of crucial importance. The …
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The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes – Executive summary
2009 - The International Xenotransplantation Association islet xenotransplantation consensus statement describes the conditions for undertaking clinical trials of porcine islet products in type 1 diabetes. …
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