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1. Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS

   2009 - During evolutionary adaptation in the immune system, host defense is traded off against autoreactivity. Signals through the costimulatory receptor CD28 enable T cells to respond specifically to …

2. Prolongierter Verlauf einer durch Zeckenstich übertragenen ulzeroglandulären Tularämie bei einer 20-jährigen Patientin

   2009 - ANAMNESE UND KLINISCHER BEFUND: Eine 20-jährige Patientin wurde wegen einer anhaltend schmerzhaften Lymphknotenschwellung (LKS) in der rechten Axilla zur infektiologischenAbklärung vorgestellt. Sie …

3. Influenza A virus TRIMs the type I interferon response

   2009 - The virulence of many pathogenic viruses depends on suppression of the innate type I interferon defense. For influenza viruses, a unique strategy has now been unraveled, as the viral nonstructural …

4. Indigenous hepatitis E virus infection of a plasma donor in Germany

   2009 - Background Although Europe is supposed to be non-endemic for Hepatitis E virus (HEV), locally acquired human cases are registered, and a relatively high prevalence for anti-HEV was found in blood …

5. Autophagy induction by trehalose counteracts cellular prion infection

   2009 - Prion diseases are fatal neurodegenerative and infectious disorders for which no therapeutic or prophylactic regimens exist. In search of cellular mechanisms that play a role in prion diseases and …

6. Unsung hero Robert C. Gallo

   2009 - Awarding the Nobel prize in physiology or medicine to Francoise Barré-Sinoussi and Luc Montagnier for the discovery of HIV-1, the causative agent of AIDS, is timely given the harm that the virus …

7. Human embryonic stem cell lines and their use in international research

   2009 - Research in human pluripotent stem cells, including human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPSC), is one of the most dynamic research fields. Despite the high …

8. Cowpox Virus Infection in Pet Rat Owners - Not Always Immediately Recognized

   2009 - Background: The aim of this article is to make physicians of all specialties aware of the possible variations of clinical course in human cowpox infection. This has been a matter of current interest …

9. Entwicklung und Evaluation der nationalen Gesundheitsziele für Kinder und Jugendliche: Welchen Beitrag leistet der Kinder- und Jugendgesundheitssurvey des Robert Koch-Instituts (KiGGS)?

   2009 - Gesundheitsziele werden zunehmend zu einem Steuerungsinstrument der Gesundheitspolitik im nationalen und internationalen Kontext. Im Projekt gesundheitsziele.de wurden mit Blick auf Kinder und …

10. Survivin minigene DNA vaccination is effective against neuroblastoma

    2009 - The inhibitor of apoptosis protein survivin is highly expressed in neuroblastoma (NB) and survivin-specific T cells were identified in Stage 4 patients. Therefore, we generated a novel survivin …

11. Inhibition of growth of Shiga toxin-producing Escherichia coli by non-pathogenic Escherichia coli

    2009 - During routine quality control testing of diagnostic methods for Shiga toxin-producing Escherichia coli (STEC) using stool samples spiked with STEC, it was observed that the Shiga toxin could not be …

12. Porcine circoviruses--small but powerful

    2009 - When porcine circovirus type 1 (PCV1) was isolated more than 40 years ago as a non-pathogenic contaminant of a porcine kidney cell line, enthusiasm and curiosity kept within reasonable limits. …

13. Über die Bedeutung von Schutzimpfungen

    2009 - Infektionskrankheiten stellten in der Vergangenheit die häufigste Todesursache dar. Schutzimpfungen, die Verbesserung der Hygiene, der Ernährung und der therapeutischen Möglichkeiten sowie die …

14. Kostenaspekte bei Planung und Betrieb von biologischen Hochsicherheitslaboratorien

    2009 - Planung, Bau und Betrieb von biologischen Hochsicherheitsanlagen der Schutzstufen 3 und 4 sind nicht zuletzt wegen der aufwendigen technischen Ausstattung mit hohen Kosten verbunden. Einen …

15. Cluster of hepatitis A cases among travellers returning from Egypt, Germany, September through November 2008

    2009 - From September to November 2008, 34 cases of hepatitis A imported from Egypt were reported to the German public health authorities. Investigations point to a continuing common source of infection, …

16. Sleep duration and blood pressure in children: a cross-sectional study

    2009 - OBJECTIVES: Short sleep duration as a risk factor for higher blood pressure has been reported by several studies on adults. This study aimed to investigate this association in children, considering …

17. Epidemiologie und Pathogenese der Influenza

18. Aufrechterhaltung der Versorgung mit Blutprodukten im Falle einer Influenza-Pandemie. Mitteilungen des Arbeitskreises Blut des Bundesministeriums für Gesundheit

19. A neutralization assay for HIV-2 based on measurement of provirus integration by duplex real-time PCR

    2009 - Specific, effective and rapid neutralization assays are crucial for the development of an HIV vaccine based on the stimulation of neutralizing antibodies and the development of such an assay for …

20. Low ankle-brachial index predicts cardiovascular risk after acute cerebral ischemia

    2009 - Background and Purpose—A low ankle-brachial blood pressure index (ABI) is an established risk marker for cardiovascular disease and mortality in the general population, but little is known about its …

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