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1. RNA helicase retinoic acid-inducible gene I (RIG-I) as a sensor of Hantaan virus (HTNV) replication

   2011 - Hantaan virus (HTNV) causes severe human disease. The HTNV genome consists of three ssRNA segments of negative polarity which are complexed with viral nucleocapsid (N) protein. How the human innate …

2. Legionella pneumophila induced IκBζ-dependent expression of il-6 in lung epithelium

   2011 - Legionella pneumophila causes severe community- and hospital-acquired pneumonia. Lung airway and alveolar epithelial cells comprise an important sentinel system in airborne infections. Although …

3. Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly

   2011 - Background The HIV-1 p6 Gag protein regulates the final abscission step of nascent virions from the cell membrane by the action of two late assembly (L-) domains. Although p6 is located within one of …

4. Gestational weight gain and overweight in children: Results from the cross-sectional German KiGGS study

   2011 - Objective. Gestational weight gain (GWG) has been associated with overweight in offspring. The aim of the study was to assess the association of GWG with childhood overweight and a potential effect …

5. Livestock-associated methicillin-resistant Staphylococcus aureus in humans, Europe

   2011 - To estimate the proportion of methicillin-resistant Staphylococcus aureus (MRSA) isolates from humans that were sequence type (ST) 398, we surveyed 24 laboratories in 17 countries in Europe in 2007. …

6. A national cross-sectional study on socio-behavioural factors that influence physicians' decisions to begin antimicrobial therapy

   2011 - Purpose   Current efforts to prevent antimicrobial resistance include limiting antimicrobial use, providing education about appropriate use, and developing better point-of-care tests, but what do …

7. The Hepatitis C epidemic among HIV-positive men who have sex with men: incidence estimates from 1990 to 2007

   2011 - Background: Outbreaks of acute hepatitis C virus (HCV) infection among HIV-infected men having sex with men (MSM) have been described since 2000. However, phylogenetic analysis suggests that the …

8. Generation and characterisation of monoclonal antibodies against influenza virus A, subtype H5N1

   2011 - The emergence of highly pathogenic avian influenza A virus (HPAIV) subtype H5N1 in 1997 has since resulted in large outbreaks in poultry and in transmission from poultry to humans, mostly in southeast …

9. The IFN-γ-inducible GTPase, irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

   2011 - Clearance of infection with intracellular pathogens in mice involves interferon-regulated GTPases of the IRG protein family. Experiments with mice genetically deficient in members of this family such …

10. Increased Neutralizing Antibody Response after Simultaneous Immunization with Leucogen and the Feline Leukemia Virus Transmembrane Protein

    2011 - To develop improved vaccination strategies against feline leukemia virus (FeLV), rats were immunized with the transmembrane envelope protein p15E of FeLV alone or in combination with the commercial …

11. LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo

    2011 - Serum lactate dehydrogenase (LDH) is a well-known clinical surrogate parameter. A high activity of LDH is associated with a poor prognosis in different tumor types. Here we demonstrate by a gene …

12. Inhibition of poxvirus spreading by the anti-tumor drug Gefitinib (Iressa™)

    2011 - The threat of smallpox virus as a bioterrorist weapon is raising international concerns again since the anthrax attacks in the USA in 2001. The medical readiness of treating patients suffering from …

13. European Risk Assessment Guidance for Infectious Diseases transmitted on Aircraft – the RAGIDA project

    2011 - In order to assist national public health authorities in the European Union to assess the risks associated with the transmission of infectious agents on board aircrafts, the European Centre for …

14. Intra- and interspecies genomic transfer of the Enterococcus faecalis pathogenicity island

    2011 - Enterococci are the third leading cause of hospital associated infections and have gained increased importance due to their fast adaptation to the clinical environment by acquisition of antibiotic …

15. No evidence for transmission of SIVwrc from western red colobus monkeys (Piliocolobus badius badius) to wild west African chimpanzees (Pan troglodytes verus) despite high exposure through hunting

    2011 - Background Simian Immunodeficiency Viruses (SIVs) are the precursors of Human Immunodeficiency Viruses (HIVs) which have lead to the worldwide HIV/AIDS pandemic. By studying SIVs in wild primates we …

16. Characterization of Escherichia coli Strains Isolated from Diarrhea Patients in Sao Paulo: Identification of Intermediate Virulence Factor Profiles by Multiplex PCR

    2011 - Intestinal pathogenic Escherichia coli is a major causative agent of severe diarrhea. In this study the prevalence of different pathotypes among 702 Brazilian diarrhea E. coli isolates was determined …

17. A multiresistance megaplasmid pLG1 bearing a hy(lEfm) genomic island in hospital Enterococcus faecium isolates

    2011 - Enterococcus faecium is considered to be a nosocomial pathogen with increasing medical importance. The putative virulence factor, hylEfm, encoding a putative hyaluronidase, is enriched among the …

18. Prevalence and complications of orthostatic dizziness in the general population

    2011 - Although orthostatic dizziness (OD) is a common complaint, its prevalence and medical impact in the general population are unknown. The study aims to assess prevalence, medical sequelae and healthcare …

19. Generation of neutralising antibodies against porcine endogenous retroviruses (PERVs)

    2011 - Antibodies neutralising porcine endogenous retroviruses (PERVs) were induced in different animal species by immunisation with the transmembrane envelope protein p15E. These antibodies recognised …

20. A modified self-controlled case series method to examine association between multidose vaccinations and death

    2011 - The self-controlled case series method (SCCS) was developed to analyze the association between a time-varying exposure and an outcome event. We consider penta- or hexavalent vaccination as the …

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